Identification of alcohol preference relevant genes in QTL on mouse chromosome 2
| Autor: | Lishi Wang, Yue Huang, Beth Bennett, Weikuan Gu, Yan Jiao, Griffin Gibson, Kristin M. Hamre, Xiaoyun Liu, Robert W. Williams |
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| Rok vydání: | 2011 |
| Předmět: |
Genetics
Candidate gene Applied Mathematics food and beverages Chromosome Single-nucleotide polymorphism Quantitative trait locus Biology lcsh:Computer applications to medicine. Medical informatics Bioinformatics Biochemistry Computer Science Applications lcsh:Biology (General) Family-based QTL mapping Structural Biology Meeting Abstract Gene expression lcsh:R858-859.7 DNA microarray lcsh:QH301-705.5 Molecular Biology Gene |
| Zdroj: | BMC Bioinformatics BMC Bioinformatics, Vol 12, Iss Suppl 7, p A2 (2011) |
| ISSN: | 1471-2105 |
| DOI: | 10.1186/1471-2105-12-s7-a2 |
| Popis: | Results By using the keyword alcohol, we identified a total of 39 genetic elements in the region between markers D2Mit56 and D2Mit10. Among these genetic elements, we found seven with potential function in alcohol preference (Table 1). We then examined the SNPs, insertions and deletions, and gene expression levels of those seven genes. Conclusions Our current data suggest that the Atf2 and Titin genes are potentially the most alcohol relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified. |
| Databáze: | OpenAIRE |
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