Radiation Sensitivity of Visual and Oculomotor Pathways
| Autor: | Gerald Langmann, O. Schröttner, Michael Mokry, K. Leber, J. Berglöff, Gerhard Pendl |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Eye disease medicine.medical_treatment Radiosurgery Radiation Tolerance Central nervous system disease Radiation sensitivity Oculomotor Nerve medicine Humans Cranial nerve disease Visual Pathways Radiation Injuries Retrospective Studies Brain Neoplasms business.industry Cranial nerves medicine.disease Cranial Nerve Diseases Surgery Optic nerve sense organs Neurology (clinical) medicine.symptom business Complication |
| Zdroj: | Stereotactic and Functional Neurosurgery. 64:233-238 |
| ISSN: | 1423-0372 1011-6125 |
| DOI: | 10.1159/000098784 |
| Popis: | Adverse effects of stereotactic radiosurgery on cranial nerves, especially the optic nerve and its pathways, are not yet sufficiently understood. 29 patients who underwent Gamma Knife radiosurgery for benign skull base tumors were reviewed. In all of them, parts of the visual pathways and/or other cranial nerves in the middle cranial fossa received significant doses of radiation. The dose given was correlated with neuro-ophthalmological findings during a follow-up period of 6-24 months. Cranial nerves III, IV and VI within the cavernous sinus, exposed to a dose from 4.5 to 30 Gy, did not develop signs of a neuropathy. Neither did the trigeminal nerve which received between 5 and 20 Gy. In patients with normal neuro-ophthalmological findings prior to radiosurgery, the visual pathways tolerated a dose between 7.5 to 15 Gy. However, in a group of patients with visual deficits before treatment and where the visual fibers received between 6 and 16.6 Gy, 31% deteriorated afterwards. These results indicate that the visual pathways are more at risk for radiation damage than the other cranial nerves in the region and that they may be even more vulnerable to radiation if prior to radiosurgery their function has been compromised by tumor or previous surgery. |
| Databáze: | OpenAIRE |
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