Perfusion of the uterine junctional zone in nulliparous and primiparous women assessed by DCE-MRI, as a function of menstrual cycle and hormonal contraception
| Autor: | Leen Wijnen, Marjan Vandersteen, L. J. Meylaerts, Willem Ombelet, Marc Bazot, Martin Grieten |
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| Přispěvatelé: | MEYLAERTS, Liesbeth, Wijnen, L., Bazot, M., Grieten, M., OMBELET, Willem, VANDERSTEEN, Marjan |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject Population Biomedical Engineering Biophysics Contrast Media Cervix Uteri Luteal phase 030218 nuclear medicine & medical imaging Contraceptives Oral Hormonal 03 medical and health sciences 0302 clinical medicine Follicular phase Image Processing Computer-Assisted DCE-MRI perfusion junctional zone outer myometrium nulliparous primiparous Medicine Humans Radiology Nuclear Medicine and imaging education Cervix Menstrual cycle Menstrual Cycle media_common Gynecology education.field_of_study business.industry Uterus Myometrium Magnetic Resonance Imaging Perfusion Parity medicine.anatomical_structure Hormonal contraception 030220 oncology & carcinogenesis Area Under Curve Female business |
| Popis: | Purpose: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Material and methods: We performed pelvic 1.5 T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26.4, 25.8, 3023 and 28.18 years). The nulliparous non-users underwent DCE-MRI investigations during their follicular, ovulatory and luteal phase. Perfusion parameters (iAUC/volume, Ktrans, Kep and Ve) were assessed in the anterior and posterior junctional zone (JZ), outer myometrium and cervix. Results: In nulliparous non-users, the mean Ktrans and iAUC/volume showed a decrease from follicular to luteal phase (0.82 vs 0.55 min(-1) for Ktrans, p = 0/027 and 1.28 vs 0.68 for iAUC/volume, p < 0.001). The anterior JZ demonstrated lower Ktrans (p = 0.050) and higher Kep (p = 0.012), in nulliparous non-users, lower Ktrans in nulliparous users (p < 0.001) and lower Ve in primiparous users (p = 0.012) than the anterior outer myometrium. Ktrans at the anterior and posterior JZ wall in nulliparous users was lower than in non-users (p = 0.001 and p = 0.013) and Ve at the anterior JZ wall in primiparous users was lower than in non-users (p = 0.044). Conclusion: This study provides data on normal perfusion parameters of inner and outer myometrium, which may be potentially useful in assisted reproductive therapy. (C) 2016 Elsevier Inc All rights reserved. This research was supported by the Department of Medical Imaging at Ziekenhuis Oost-Limburg, Genk, Belgium. |
| Databáze: | OpenAIRE |
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