Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal Carcinoma

Autor: Jun Li, Minzhong Tang, Yuming Zheng, Weiming Zhong, Ai-Ying Lu, Huihui Wu, Yong-Lin Cai, Ningjiang Ou, Jianquan Gao, Hai-Feng Li
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Pathology
Neutrophils
Lymphocyte
lcsh:Medicine
Gastroenterology
Monocytes
0302 clinical medicine
Lymphocytes
Stage (cooking)
Child
Nasopharyngeal Carcinoma
General Medicine
Middle Aged
Survival Rate
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Research Article
Adult
Blood Platelets
medicine.medical_specialty
Adolescent
Article Subject
Nasopharyngeal neoplasm
Disease-Free Survival
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Internal medicine
medicine
Carcinoma
Humans
Lymphocyte Count
Neutrophil to lymphocyte ratio
Survival rate
Aged
General Immunology and Microbiology
Platelet Count
business.industry
Monocyte
lcsh:R
fungi
Nasopharyngeal Neoplasms
medicine.disease
body regions
030104 developmental biology
Nasopharyngeal carcinoma
business
Zdroj: BioMed Research International
BioMed Research International, Vol 2017 (2017)
ISSN: 2314-6133
DOI: 10.1155/2017/3047802
Popis: The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival. Cox proportional hazard regression analysis was used to reveal the independent factors affecting the prognosis of NPC patients. NLR was associated with T staging, N staging, and overall clinical stage grouping of the NPC patients (P<0.05). NLR ≥ 2.28, LMR < 2.26, and PLR ≥ 174 were significantly associated with a relatively short overall survival (P<0.05). In addition, NLR ≥ 2.28 was significantly associated with a relatively short progression-free survival (P<0.05). Cox proportional hazard regression analysis showed that NLR was an independent prognostic factor in NPC. Pretreatment NLR, LMR, and PLR might be a useful complement to TNM staging in the prognostic assessment of NPC patients.
Databáze: OpenAIRE
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