pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin
| Autor: | Li Yuling, Du Baixiang, Caihong Zhu, Hena Zhang, Kang Xu, Leran Bu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polymers
Diol Polyurethanes Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Micelle 03 medical and health sciences chemistry.chemical_compound Lactones 0302 clinical medicine Drug Delivery Systems Amphiphile Polymer chemistry micelle medicine Polyamines Doxorubicin poly(2-ethyl-2-oxazoline) Particle Size Caproates Micelles Polyurethane Drug Carriers lcsh:RM1-950 General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Controlled release 2-ethyl-2-oxazoline dual- responsive lcsh:Therapeutics. Pharmacology chemistry polyurethane Delayed-Action Preparations Drug delivery drug delivery 0210 nano-technology medicine.drug Research Article |
| Zdroj: | Drug Delivery, Vol 26, Iss 1, Pp 300-308 (2019) Drug Delivery |
| DOI: | 10.6084/m9.figshare.7873508 |
| Popis: | We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz-b-PU(SS)-b-PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. And reduction sensitivity was induced via disulfide bonds incorporated into the hydrophobic poly (ε-caprolactone) segment of the amphiphilic PUs. The system can self-assemble to form micelles responsive to pH and reducing conditions. The properties of the micelle were studied with dynamic light scattering and scanning electron microscopy. Doxorubicin (DOX) was chosen as a model drug. The in vitro release studies showed that PEtOz-b-PU(SS)-b-PEtOz micelle could degrade more rapidly and completely in a reductive and acidic environment [10 mM dl-Dithiothreitol, pH 5.0]. The methyl tetrazolium (MTT) assay and fluorescent microscopy confirmed the cytotoxicity of the DOX-loaded micelles. This work provides a promising dual-responsive drug carrier based on amphiphilic PU to achieve efficient drug delivery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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