The influence of an angiotensin II antagonist, saralasin, given before donor nephrectomy, on kidney function after transplantation. A controlled prospective study
| Autor: | Doehn N, Clausen C, Huland H, Bause Hw |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Urology Renal function urologic and male genital diseases Kidney Nephrectomy chemistry.chemical_compound Ischemia Internal medicine Renin–angiotensin system medicine Humans Prospective Studies Child Transplantation business.industry Angiotensin II Acute Kidney Injury Kidney Transplantation Diuresis Endocrinology medicine.anatomical_structure chemistry Anuria Female medicine.symptom business Saralasin Bilateral Nephrectomy |
| Zdroj: | Transplantation. 36(2) |
| ISSN: | 0041-1337 |
| Popis: | Kidneys from cadaver donors who had been treated during the last 10 min before bilateral nephrectomy with an infusion of 10 micrograms/kg-1/min-1 (Sar1, Val5, Ala8)-angiotensin II had a remarkable, significantly lower percentage of acute renal failure (25%) after renal transplantation than untreated kidneys (58.3%). Anuria was seen in the treated group only in 4.2%, although it occurred in the untreated control group in 16.6%. The role of the activated renin-angiotensin system in postischemic acute renal failure is discussed. |
| Databáze: | OpenAIRE |
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