3 Tesla breast MR imaging as a problem-solving tool: Diagnostic performance and incidental lesions

Autor: Pascal A. T. Baltzer, Peter Brader, Pia Reittner, Claudio Spick, Klaus W. Preidler, Dieter H. Szolar, M. Tillich, Katharina Rauch
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Biopsy
lcsh:Medicine
Pathology and Laboratory Medicine
030218 nuclear medicine & medical imaging
Diagnostic Radiology
0302 clinical medicine
Ultrasound Imaging
Medicine and Health Sciences
Breast MRI
Medical Personnel
Breast
lcsh:Science
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
Magnetic Resonance Imaging
Professions
Oncology
030220 oncology & carcinogenesis
Female
Radiology
Research Article
Mammography
Adult
medicine.medical_specialty
Imaging Techniques
Histopathology
Surgical and Invasive Medical Procedures
Malignancy
Research and Analysis Methods
03 medical and health sciences
Young Adult
Breast cancer
Signs and Symptoms
Diagnostic Medicine
Radiologists
medicine
Cancer Detection and Diagnosis
Humans
Aged
Retrospective Studies
business.industry
lcsh:R
Magnetic resonance imaging
Retrospective cohort study
medicine.disease
Cross-Sectional Studies
Anatomical Pathology
People and Places
Lesions
lcsh:Q
Population Groupings
business
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0190287 (2018)
ISSN: 1932-6203
Popis: Purpose To investigate the diagnostic performance and incidental lesion yield of 3T breast MRI if used as a problem-solving tool. Methods This retrospective, IRB-approved, cross-sectional, single-center study comprised 302 consecutive women (mean: 50±12 years; range: 20–79 years) who were undergoing 3T breast MRI between 03/2013-12/2014 for further workup of conventional and clinical breast findings. Images were read by experienced, board-certified radiologists. The reference standard was histopathology or follow-up ≥ two years. Sensitivity, specificity, PPV, and NPV were calculated. Results were stratified by conventional and clinical breast findings. Results The reference standard revealed 53 true-positive, 243 true-negative, 20 false-positive, and two false-negative breast MRI findings, resulting in a sensitivity, specificity, PPV, and NPV of 96.4% (53/55), 92.4% (243/263), 72.6% (53/73), and 99.2% (243/245), respectively. In 5.3% (16/302) of all patients, incidental MRI lesions classified BI-RADS 3–5 were detected, 37.5% (6/16) of which were malignant. Breast composition and the imaging findings that had led to referral had no significant influence on the diagnostic performance of breast MR imaging (p>0.05). Conclusion 3T breast MRI yields excellent diagnostic results if used as a problem-solving tool independent of referral reasons. The number of suspicious incidental lesions detected by MRI is low, but is associated with a substantial malignancy rate.
Databáze: OpenAIRE
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