Abrogation of Bronchial Eosinophilic Inflammation and Attenuated Eotaxin Content in Protease-Activated Receptor 2-Deficient Mice
| Autor: | Takuya Hara, Toshiaki Takizawa, Junichi Kawagoe, Masaki Tamiya, Yukio Hattori, Jiro Matsumoto, Naohiro Saito, Toru Kanke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Eotaxin
Chemokine CCL11 Proteases Tryptase Allergic inflammation Mice medicine Animals Receptor PAR-2 Lung Protease-activated receptor 2 Pharmacology Mice Knockout medicine.diagnostic_test biology Chemistry lcsh:RM1-950 Eosinophil respiratory system Asthma respiratory tract diseases Eosinophils Mice Inbred C57BL Ovalbumin Bronchoalveolar lavage medicine.anatomical_structure lcsh:Therapeutics. Pharmacology Chemokines CC Immunology biology.protein Molecular Medicine |
| Zdroj: | Journal of Pharmacological Sciences, Vol 98, Iss 1, Pp 99-102 (2005) |
| ISSN: | 1347-8613 |
| Popis: | Protease-activated receptor 2 (PAR2) belongs to the PAR family (PAR1 to PAR4), which is activated by serine proteases (trypsin, tryptase, etc.). In this study, we evaluated the role of PAR2 in allergic inflammation of airways using PAR2-deficient (PAR2−/−) mice. In wild-type mice, infiltration of eosinophils and high eotaxin content were found in bronchoalveolar lavage fluid (BALF) after ovalbumin (OA) sensitization and following challenge. In contrast, both OA-induced infiltration of eosinophils and increase of eotaxin content were abrogated in BALF from PAR2−/− mice. The activation of PAR2 might be essential in the production of eotaxin and consequential allergic inflammation in airways. Keywords:: protease-activated receptor 2, eosinophil, eotaxin |
| Databáze: | OpenAIRE |
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