Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck

Autor: Johan H Roos, Antti Mäkitie, Jussi Tarkkanen, Taru Ilmarinen
Přispěvatelé: Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, Clinicum, Research Program in Systems Oncology, HUSLAB, Department of Pathology
Rok vydání: 2021
Předmět:
Zdroj: European Archives of Oto-Rhino-Laryngology. 279:3147-3155
ISSN: 1434-4726
0937-4477
DOI: 10.1007/s00405-021-07162-0
Popis: Background Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common. Methods This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival. Results The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS. Conclusions Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size.
Databáze: OpenAIRE
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