The mechanisms of leukocyte removal by filtration
| Autor: | Jan Feijen, Anton Bruil, Willem G. van Aken, Tom Beugeling |
|---|---|
| Přispěvatelé: | Faculty of Science and Technology, Biomaterials Science and Technology |
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_treatment
Clinical Biochemistry Cell Separation Biology Leukocyte filtration law.invention law Leukocytes medicine Humans METIS-105368 Leukapheresis Filtration IR-9849 Mechanism (biology) Biochemistry (medical) Immunosuppression Hematology Models Theoretical Review article Histocompatibility Immunology Blood Component Removal Leukocyte depletion |
| Zdroj: | Transfusion medicine reviews, IX(2), 145-166. W.B. Saunders Ltd |
| ISSN: | 0887-7963 |
| Popis: | ONVINCING evidence exists that blood transfusions are associated with deleterious effects caused by residual leukocytes in blood and blood components. These side effects include alloimmunization to histocompatibility antigens, transmission of viruses, immunosuppression and graft-versus-host disease (GVHD). Leukocyte depletion of blood components may prevent or ameliorate some of these harmful effects. Among the various methods to remove or reduce leukocytes in blood components, filters have been shown to be most efficient. However, the mechanism of leukocyte depletion by such filters is not completely understood, which limits the development of improved, cost-effective, and clinically applicable filter materials. The aim of this review article is to discuss the development of leukocyte filters, the various mechanisms of leukocyte filtration, and mathematical models to describe the process of leukocyte filtration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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