TAFRO Syndrome in a Patient of South-American Descent
| Autor: | Cecilia Cabral, Augusto Castroagudin, Tatiana Uehara, Enrique Darderes, Damián M. Contardo, Natalia Gabriela Deligiannis, Horacio di Fonzo, Paola Finocchietto, Claudia Papini |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Pleural effusion business.industry Microcytic anemia lcsh:R lcsh:Medicine medicine.disease Asymptomatic Gastroenterology Organomegaly Castleman disease TAFRO syndrome Methylprednisolone hemic and lymphatic diseases Internal medicine Ascites Internal Medicine medicine Rituximab medicine.symptom Myelofibrosis business medicine.drug |
| Zdroj: | European Journal of Case Reports in Internal Medicine, Vol 2, Iss 4 (2015) |
| ISSN: | 2284-2594 |
| DOI: | 10.12890/000220 |
| Popis: | A 31-year-old Caucasian woman of South-American descent was diagnosed with a variant of multicentric Castleman disease (MCD) that has been reported in Japan as Castleman-Kojima disease. This is a systemic inflammatory disorder known as TAFRO Syndrome which includes thrombocytopenia, polyserositis (ascites/pleural effusion), microcytic anemia, myelofibrosis, fever, renal dysfunction and organomegaly, with immunologic disorder, polyclonal hypergammaglobulinemia, and elevated levels of interleukin-6 (IL-6) and the vascular endothelial growth factor present in serum and/or effusions. Optimal therapies are not well established. The patient was treated with methylprednisolone and rituximab. Following the start of treatment, the patient has been asymptomatic for over 8 months. This is one of only a few reports of TAFRO Syndrome in a non-Japanese patient. |
| Databáze: | OpenAIRE |
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