Time Course of Inflammatory and Procoagulant Markers in the Early Period After Total Hip Replacement
| Autor: | Ana Mavric, Paula Maia, Sandra Haddad, Peter Poredos, Lara Leben, Jawed Fareed, Pavel Poredos, Mojca Bozic Mijovski, Mateja K Jezovnik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Period (gene) Lymphocyte Arthroplasty Replacement Hip Total hip replacement cardiovascular complications 030204 cardiovascular system & hematology thromboembolic complications Gastroenterology Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Thromboembolism medicine Humans Platelet 030212 general & internal medicine Postoperative Period Prospective Studies perioperative stress response Blood Coagulation Aged business.industry Hematology General Medicine Middle Aged Blood Coagulation Factors total hip replacement systemic inflammatory markers Point of delivery medicine.anatomical_structure Treatment Outcome Coagulation lcsh:RC666-701 Hemostasis Time course Female Original Article Inflammation Mediators business Biomarkers |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) Clinical and Applied Thrombosis/Hemostasis |
| ISSN: | 1938-2723 |
| Popis: | Our study aimed to investigate the levels and time-course of systemic inflammatory and hemostasis markers in the early postoperative period in patients undergoing total hip replacement (THR). The study included 70 patients of both sexes, average age 68.4 ± 10.9 years. Levels of inflammatory and hemostasis markers were measured before surgery (POD 0), a day after the surgery (POD 1) and 5 days after surgery (POD 5). In the postoperative period inflammatory markers increased. The operation provoked a significant increase of CRP on POD 1 in comparison to POD 0 (68.5 ± 5.4 vs 6.8 ± 2.2 μg/mL, p < 0.001) and the additional increase was registered on POD 5 (87.5 ± 8.1 vs 68.5 ± 5.4 μg/mL, p < 0.001). Interleukin-6 significantly increased on POD 1 (251.5 ± 21.6 vs 14.6 ± 7.1 μg/mL, p < 0.001) and after that (POD 5) decreased. After surgery leukocyte count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio were significantly higher compared to POD 0. Activation of coagulation in the postoperative period was shown by increased peak thrombin on POD 5 in comparison to POD 0 (185 ± 27 vs. 124 ± 31 nM, p < 0.001). D-dimer was increased on POD 1 and an additional rise was observed on POD 5. vWF also progressively increased in the observed period. Results of our study showed that after THR systemic inflammatory markers increased and coagulation function was enhanced. Determination of inflammatory and procoagulant markers could help identify patients at risk for cardiovascular thromboembolic events. |
| Databáze: | OpenAIRE |
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