Evaluation of the prognostic value of neutrophil to lymphocyte ratio in patients with hypertriglyceridemia-induced acute pancreatitis
| Autor: | Yuchen Wang, Bashar M. Attar, Palash Jaiswal, Harry E Fuentes, Melchor Demetria |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Neutrophils Endocrinology Diabetes and Metabolism Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Disease severity Internal medicine Humans Medicine In patient Lymphocytes Neutrophil to lymphocyte ratio Retrospective Studies Hypertriglyceridemia Inflammation Hepatology business.industry fungi Acute kidney injury Red blood cell distribution width medicine.disease Surgery Systemic inflammatory response syndrome Pancreatitis 030220 oncology & carcinogenesis Acute Disease Acute pancreatitis 030211 gastroenterology & hepatology business Biomarkers |
| Zdroj: | Pancreatology. 17:893-897 |
| ISSN: | 1424-3903 |
| Popis: | Recent studies attribute promising prognostic values to various inflammatory biomarkers in acute pancreatitis, including the following: the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW). We aimed to determine the performance of these biomarkers for detecting disease severity in patients with hypertriglyceridemia-induced acute pancreatitis (HTG-AP).We retrospectively reviewed 110 patients with HTG-AP and compared the NLR, PLR, and RDW in different severity groups. We performed receiver-operating characteristic (ROC) analysis to identify the optimal cut-off value for NLR to predict severe AP.NLR was significantly higher in patients with severe AP than mild and moderately severe AP (14.6 vs. 6.9, p 0.001), and higher with organ failure upon presentation (9.1 vs. 7.1, p = 0.026). After dichotomization by the optimal cut-off value of 10 as determined by the ROC curve, the high-NLR group had a significantly longer length of stay (9.1 vs. 6.6 days, p = 0.001), duration of nil per os (4.9 vs. 3.7 days, p = 0.007), and higher rates of complications, including systemic inflammatory response syndrome (81.5% vs. 44.6%, p = 0.001) and persistent acute kidney injury (25.9% vs. 3.6%, p 0.001). High NLR independently predicted severe acute pancreatitis in multivariate analysis (Odds ratio 6.71, p = 0.019).NLR represents an inexpensive, readily available test with a promising value to predict disease severity in HTG-AP. Among the three inflammatory biomarkers, NLR has the highest discriminatory capacity for severe HTG-AP, with an optimal cut-off value of 10. |
| Databáze: | OpenAIRE |
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