Changed inflammatory markers after application of 4DryField PH for adhesion prevention in gynecological surgery
| Autor: | Nicole Ziegler, Luz Angela Torres-de la Roche, Rajesh Devassy, Rudy Leon De Wilde |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adhesiolysis Wilcoxon signed-rank test medicine.medical_treatment Adhesion (medicine) Tissue Adhesions Inflammation Peritoneal Diseases Peritoneal adhesion Peritoneal adhesions Gastroenterology Gynecologic Surgical Procedures Postoperative Complications Internal medicine Humans Medicine Clinical significance Adhesion prevention Gynecological surgery Retrospective Studies Hemostasis business.industry Obstetrics and Gynecology General Medicine Starch-based polysaccharide medicine.disease Adhesion prophylaxis Female General Gynecology medicine.symptom business Inflammation markers |
| Zdroj: | Archives of Gynecology and Obstetrics |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-021-06095-7 |
| Popis: | IntroductionThe development of peritoneal adhesions and the effects of different antiadhesion agents on such mechanisms are not fully understood. Temporary rises of the C-reactive protein (CRP) level have been reported after antiadhesion agent application. We present the changes of inflammation markers observed after use of a starch-based polysaccharide certified for adhesion prevention and hemostasis 4DF (4DryField®PH).MethodRetrospective comparative analysis of inflammation markers in 40 patients undergoing laparoscopic adhesiolysis with or without adhesion prophylaxis was conducted. Statistical comparisons were performed by means of paired or unpairedttests (for normally distributed continuous data), Wilcoxon matched pairs signed-rank tests or Mann–Whitney tests (for not-normally distributed continuous data), Mantel–Cox tests (for continuous data describing time intervals), and Fisher’s exact tests (for discrete data).ResultsThe maximum post-operative CRP level was significantly elevated in the 4DF group (87 vs. 29%;p ConclusionThe starch-based polysaccharide 4DF can be considered safe and does not induce inflammatory reactions of clinical significance. Further studies regarding 4DF degradation are recommended and, apart from macrophage migration, could also examine corresponding markers such as IL-6 and PCT. |
| Databáze: | OpenAIRE |
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