A Direct Approach to Orthogonally Protected α-Amino Aldehydes
| Autor: | Vincent L. Revil-Baudard, Samir Z. Zard, Richard Lamb |
|---|---|
| Přispěvatelé: | Laboratoire de synthèse organique (DCSO), École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Aldehyde Combinatorial chemistry 3. Good health 0104 chemical sciences Adduct Physical and Theoretical Chemistry ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Organic Letters Organic Letters, American Chemical Society, 2019, 21 (16), pp.6352-6356. ⟨10.1021/acs.orglett.9b02237⟩ |
| ISSN: | 1523-7060 1523-7052 |
| Popis: | O-Neopentyl-xanthate 19 bearing a masked α-amino aldehyde, with the two functional groups orthogonally protected, reacts cleanly with many functional alkenes. The radical addition–transfer furnishes densely functionalized adducts that can be further transformed into an array of amino-substituted carbocycles and heteroaromatics. They are also easily converted into imidazolones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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