Half a century of neural prepatterning: the story of a few bristles and many genes
| Autor: | José Luis Gómez-Skarmeta, Sonsoles Campuzano, Juan Modolell |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Fundación Ramón Areces |
| Rok vydání: | 2003 |
| Předmět: |
Nervous system
Body Patterning Achaete protein Proneural genes Biology Bristle Nervous System DNA-binding proteins Basic Helix-Loop-Helix Transcription Factors Animals Drosophila Proteins Transcription factor Gene Gene expression regulation Genetics Regulation of gene expression Body patterning General Neuroscience Gene Expression Regulation Developmental DNA-Binding Proteins Drosophila Neural differentiation Transcriptions factors Neuroscience Transcription Factors |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1471-0048 1471-003X |
| Popis: | 12 páginas, 6 figuras. In 1954, Curt Stern proposed the concept of the neural prepattern, meaning the underlying positional information in an undifferentiated epithelium that determined where neural differentiation could take place. Subsequent work gave a molecular basis to this concept, which was equated to a combination of transcription factors deployed in partially overlapping spatial domains that regulated proneural genes and, thereby, neural differentiation. Here, we review the work that, in the past few years, has identified many prepattern genes and has disclosed that their function is not limited to the regulation of proneural genes. Grants from Dirección General de Investigación Científica y Técnica, Comunidad Autónoma de Madrid, and an institutional grant from Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa are acknowledged. |
| Databáze: | OpenAIRE |
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