Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids
| Autor: | Edjane R. dos Santos, Heloisa S. Selistre-de-Araujo, Lucas V. Pozzi, Angelica E. Graminha, Fernando Rogério Pavan, Alzir A. Batista, Rodrigo S. Corrêa |
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| Přispěvatelé: | Universidade Federal de São Carlos (UFSCar), Universidade Federal de Ouro Preto, Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2017 |
| Předmět: |
Ruthenium complexes
Stereochemistry Cytotoxicity Phenanthroline chemistry.chemical_element 010402 general chemistry 01 natural sciences Diastereoisomers Inorganic Chemistry chemistry.chemical_compound Materials Chemistry medicine Physical and Theoretical Chemistry chemistry.chemical_classification Alanine Methionine 010405 organic chemistry Cycloserine Tryptophan Amino acid 0104 chemical sciences Ruthenium chemistry Glycine Anti-Mycobacterial tuberculosis medicine.drug |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0020-1693 |
| Popis: | Made available in DSpace on 2018-12-11T17:11:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,2′-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,2′-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol. Departamento de Química Universidade Federal de São Carlos, C.P. 676 Departamento de Química ICEB Universidade Federal de Ouro Preto Departamento de Ciências Fisiológicas Universidade Federal de São Carlos, C.P. 676 Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas UNESP Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas UNESP |
| Databáze: | OpenAIRE |
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