The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival

Autor: Orlow, Irene, Shi, Yang, Kanetsky, Peter A, Thomas, Nancy E, Luo, Li, Corrales-Guerrero, Sergio, Cust, Anne E, Sacchetto, Lidia, Zanetti, Roberto, Rosso, Stefano, Armstrong, Bruce K, Dwyer, Terence, Venn, Alison, Gallagher, Richard P, Gruber, Stephen B, Marrett, Loraine D, Anton-Culver, Hoda, Busam, Klaus, Begg, Colin B, Berwick, Marianne, GEM Study Group
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Oncology
haplotype
Medical and Health Sciences
Calcitriol receptor
polymorphism
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Receptors
Medicine
Melanoma
Cancer
integumentary system
Single Nucleotide
Biological Sciences
030220 oncology & carcinogenesis
Sunlight
Female
Sun exposure
UVB
medicine.medical_specialty
TaqI
SNP
interaction
Single-nucleotide polymorphism
Dermatology
Polymorphism
Single Nucleotide
survival
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Calcitriol
Internal medicine
melanoma
Genetics
Vitamin D and neurology
Humans
vitamin D receptor
Genetic Predisposition to Disease
Climate-Related Exposures and Conditions
Nutrition
business.industry
Prevention
Dermatology & Venereal Diseases
Haplotype
GEM Study Group
medicine.disease
Survival Analysis
030104 developmental biology
Haplotypes
chemistry
exposure
Immunology
Receptors
Calcitriol
business
Zdroj: Pigment cell & melanoma research, vol 31, iss 2
ISSN: 1755-1471
DOI: 10.1111/pcmr.12653
Popis: Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma-death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′ end haplotype were significant (p
Databáze: OpenAIRE
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