Cell proliferation activity and kinetic profile in the prognosis and therapeutic management of carcinoma of the pharynx and larynx
| Autor: | E N, Myers, A, Sampedro, C, Alvarez, J a, Martínez, C, Suárez, M, Alonso-Guervós, J R, de los Toyos |
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| Předmět: |
Larynx
Adult Male Pathology medicine.medical_specialty medicine.medical_treatment Flow cytometry S Phase 03 medical and health sciences 0302 clinical medicine Carcinoma Medicine Humans Neoplasm Invasiveness Prospective Studies 030223 otorhinolaryngology Grading (tumors) Laryngeal Neoplasms Aged Neoplasm Staging Ploidies medicine.diagnostic_test business.industry Cell growth Pharynx Pharyngeal Neoplasms DNA Neoplasm Middle Aged medicine.disease Flow Cytometry Prognosis Combined Modality Therapy Radiation therapy Survival Rate stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Lymphatic Metastasis Carcinoma Squamous Cell Surgery Female Radiotherapy Adjuvant Lymph business Cell Division |
| Zdroj: | ResearcherID |
| Popis: | Prognosis and management of carcinoma of the pharynx and larynx is now based on the morphologic analysis of the tumor spreading, differentiation grading, and type of microscopic invasion. The DNA ploidy status and the cell proliferation activity analyzed by flow cytometry give us complementary information about the prognosis and the management and support of the patients. We performed a study of 91 cases of carcinoma of the larynx and pharynx by means of flow cytometry. Forty-three patients were treated by surgery alone, and 48 patients also received radiotherapy. Fifty-five were aneuploid (60%); this percentage increased to 74% in the pharynx area and fell to 47% at the larynx level. The aneuploid tumors showed worse behavior in the patients treated by surgery alone compared with those who also received radiotherapy. The S-phase fraction was high in aneuploid tumors, in positive lymph nodes, and in advanced stages. The S-phase fraction was higher in poorly differentiated tumors. In patients treated by surgery alone, we noticed that by combining both cytometric variables two different kinetic profiles could be defined related to the patients’ behavior. The diploid tumors with a low S phase had the greatest rates of survival, whereas diploid tumors with a high rate of S phase and aneuploids had a lower rate. (Otolaryngol Head Neck Surg 1999;121:476-81.) |
| Databáze: | OpenAIRE |
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