Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice
| Autor: | Gasem Mohammad Abu-Taweel, Ibrahim A. Khardali, Ibrahim M. Ageel, Emad S. Shaheen, Atheer M. Mohammed, Abdulrahman F. Hakami, Eyas H. Abutawil, Magbool E. Oraiby |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aché
QH301-705.5 Physiology Anxiety Open field chemistry.chemical_compound Mice Corticosterone TBARS Medicine Biology (General) Forced swimming test biology business.industry Depression Tail suspension test biology.organism_classification language.human_language chemistry language Original Article Cannabis medicine.symptom General Agricultural and Biological Sciences business Behavioural despair test |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6097-6111 (2021) Saudi Journal of Biological Sciences |
| Popis: | Cannabis is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax. The study wanted to determine if a Cannabis extract may have an effect on how anxious and depressed the female mice behaved. forty healthy female mice were divided into four groups. Tap water was administered to the first group (control). Ethanol was administered to second group (positive control). The third and four groups were given 1 and 2 mg/kg cannabis extract respectively. Treatment continued for 14 days. After therapy, the light–dark chamber, forced swimming, tail suspension, plus lamb and open field tests were done to assess anxiety and depressive behavior. The results indicated that the anxiety and depression were increased in treated females significantly compared to control. Biochemical results showed that DA,5-HT, AChE, GSH, GST, CAT and SOD were decreased while TBARS, corticosterone and cortisol were increased. In conclusion, cannabis effects this kind of females’ behavior but the mechanisms are not clear yet. We need more researches on this trend. |
| Databáze: | OpenAIRE |
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