Prefrontal glutamate correlates of methamphetamine sensitization and preference

Autor: Lisa M. Schwartz, Ganesh Rajasekar, Katherine O. Travis, John J. Holloway, Lawrence E. Urman, Tod E. Kippin, Rianne R. Campbell, Paige N. Ruiz, Hannah M. Barrett, Melissa G. Wroten, Bailey W. Miller, Dan Maliniak, Tamara J. Phillips, Courtney L. McKenna, Kevin D. Lominac, Sema G. Quadir, Andrew B. Thompson, Karen K. Szumlinski
Přispěvatelé: Dalley, Jeffrey
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
Receptor expression
Amino Acid Transport System X-AG
Conditioning
Classical
Self Administration
Inbred C57BL
Synaptic Transmission
Methamphetamine
Mice
0302 clinical medicine
Homer Scaffolding Proteins
Receptors
AMPA
2.1 Biological and endogenous factors
Psychology
Aetiology
Central Nervous System Sensitization
Chemistry
General Neuroscience
Glutamate receptor
Substance Abuse
pre-frontal cortex
Phenotype
NMDA receptor
Cognitive Sciences
medicine.drug
N-Methyl-D-Aspartate
medicine.medical_specialty
Drug Abuse (NIDA Only)
Glutamic Acid
Prefrontal Cortex
addiction vulnerability
Basic Behavioral and Social Science
Receptors
N-Methyl-D-Aspartate
Article
03 medical and health sciences
Glutamatergic
Internal medicine
Behavioral and Social Science
medicine
Genetics
Animals
metabotropic glutamate receptor
Receptors
AMPA
Neurology & Neurosurgery
Neurosciences
Glutamic acid
Homer proteins
Classical
Brain Disorders
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Metabotropic receptor
Metabotropic glutamate receptor
Central Nervous System Stimulants
Neuroscience
030217 neurology & neurosurgery
Conditioning
Zdroj: The European journal of neuroscience, vol 43, iss 5
Lominac, KD; Quadir, SG; Barrett, HM; McKenna, CL; Schwartz, LM; Ruiz, PN; et al.(2016). Prefrontal glutamate correlates of methamphetamine sensitization and preference. EUROPEAN JOURNAL OF NEUROSCIENCE, 43(5), 689-702. doi: 10.1111/ejn.13159. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/71j334x8
ISSN: 1460-9568
Popis: Methamphetamine (MA) is a widely abused, highly addictive, psychostimulant that elicits pronounced deficits in neurocognitive function related to hypo-functioning of the prefrontal cortex (PFC). Our understanding of how repeated methamphetamine impacts excitatory glutamatergic transmission within the PFC is limited, as is information about the relation between PFC glutamate and addiction vulnerability/resiliency. In vivo microdialysis and immunoblotting studies characterized the effects of methamphetamine (10 injections of 2 mg/kg, IP) upon extracellular glutamate in C57BL/6J mice and upon glutamate receptor and transporter expression, within the medial PFC. Glutamatergic correlates of both genetic and idiopathic variance in MA preference/intake were determined through studies of high versus low MA-drinking selectively bred mouse lines (MAHDR versus MALDR, respectively) and inbred C57BL/6J mice exhibiting spontaneously divergent place-conditioning phenotypes. Repeated methamphetamine sensitized drug-induced glutamate release and lowered indices of NMDA receptor expression in C57BL/6J mice, but did not alter basal extracellular glutamate content or total protein expression of Homer proteins, or metabotropic or AMPA glutamate receptors. Elevated basal glutamate, blunted methamphetamine-induced glutamate release and ERK activation, as well as reduced protein expression of mGlu2/3 and Homer2a/b were all correlated biochemical traits of selection for high versus low methamphetamine drinking, and Homer2a/b levels were inversely correlated with the motivational valence of methamphetamine in C57BL/6J mice. These data provide novel evidence that repeated, low-dose, methamphetamine is sufficient to perturb pre- and post-synaptic aspects of glutamate transmission within the medial PFC and that glutamate anomalies within this region may contribute to both genetic and idiopathic variance in methamphetamine addiction vulnerability/resiliency.
Databáze: OpenAIRE
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