Selenium-promoted synthesis of enantiopure octahydroindolizines, hexahydro-1H-pyrrolizines and hexahydro-3H-pyrrolizin-3-ones
| Autor: | Marcello Tiecco, Luana Bagnoli, Catalina Scarponi, Lorenzo Testaferri |
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| Rok vydání: | 2008 |
| Předmět: |
ENANTIOMERICALLY PURE
INDUCED CYCLIZATION INDOLIZIDINE Organic Chemistry EFFICIENT chemistry.chemical_element Combinatorial chemistry Catalysis Inorganic Chemistry Phthalimide chemistry.chemical_compound Enantiopure drug chemistry ALKALOIDS PYRROLIZIDINE NITROGEN-HETEROCYCLES INTRAMOLECULAR HYDROAMINATION BENZENESELENENYL CHLORIDE ASYMMETRIC APPROACH Organic chemistry Hydroxymethyl Physical and Theoretical Chemistry Selenium |
| Zdroj: | Tetrahedron: Asymmetry. 19:2411-2416 |
| ISSN: | 0957-4166 |
| Popis: | Enantiomerically pure disubstituted pyrrolidines, recently synthesized from commercially available enantiomerically pure β-aminoalcohol, were used as starting materials to synthesize enantiomerically pure hexahydro-1 H -pyrrolizines and octahydroindolizine through a cyclization reaction promoted by N -(phenylseleno)phthalimide. Similarly, starting from enantiopure 5-(hydroxymethyl)pyrrolidin-2-ones, enantiopure hexahydro-3 H -pyrrolizin-3-ones were obtained. |
| Databáze: | OpenAIRE |
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