The association between nailfold capillary density and pulmonary and cardiac involvement in medium-to long-standing juvenile dermatomyositis
| Autor: | Ivar Sjaastad, Zoltan Barth, Akos Koller, Helga Sanner, Berit Flatø, Trond Mogens Aaløkken, Thomas Schwartz, May-Brith Lund |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Spirometry Vital capacity medicine.medical_specialty Adolescent Dermatomyositis Microscopic Angioscopy Pulmonary function testing Young Adult Rheumatology DLCO Diffusing capacity Internal medicine medicine Humans Lung volumes Child Lung Juvenile dermatomyositis medicine.diagnostic_test business.industry Heart medicine.disease Respiratory Function Tests medicine.anatomical_structure Heart Function Tests Cardiology Female business Follow-Up Studies |
| ISSN: | 2151-464X |
| Popis: | Objective To explore the associations between microvascular abnormalities as assessed by nailfold capillaroscopy (NFC) and pulmonary and cardiac involvement in patients with juvenile dermatomyositis (DM) who are assessed after medium‐ to long‐term follow‐up. Methods Fifty‐eight patients with juvenile DM were examined a mean ± SD of 17.0 ± 10.6 years after symptom onset. Nailfold capillary density (NCD) and a neovascular pattern (defined as an active or late scleroderma pattern) were analyzed, with blinding to clinical data. Pulmonary involvement was assessed by pulmonary function tests including spirometry, diffusing capacity for carbon monoxide (DLco ), and body plethysmography. High‐resolution computed tomography (HRCT) was also performed. Cardiac involvement was assessed by electrocardiography, Holter monitoring (heart rate variability), and echocardiography. Results Patients with low NCD ( |
| Databáze: | OpenAIRE |
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