Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy
| Autor: | Xiangao Sun, Kei Ichi Muraoka, Ken Ichi Yamamoto, Koutaro Fujimoto, Masao Yagi, Kou Ichi Shimizu, Henry R Bose, Itsuo Miyazaki, Katsuji Yoshioka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Male
T cell Recombinant Fusion Proteins Molecular Sequence Data FK506 Gene Expression Mice Inbred Strains Kidney Tacrolimus NF-κB Nephropathy chemistry.chemical_compound Mice L Cells NF-KappaB Inhibitor alpha In vivo medicine polycyclic compounds Animals Humans Interleukin 6 Nephrotoxicity Transcription factor Immunosuppressant IL-6 biology Base Sequence Interleukin-6 organic chemicals NF-kappa B General Medicine medicine.disease NFKB1 Molecular biology Immunohistochemistry Glomerular Mesangium DNA-Binding Proteins medicine.anatomical_structure chemistry biology.protein I-kappa B Proteins Oligonucleotide Probes Immunosuppressive Agents Research Article |
| Zdroj: | Journal of Clinical Investigation. 97(11):2433-2439 |
| ISSN: | 0021-9738 |
| Popis: | 金沢大学がん研究所がん分子細胞制御 FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation. We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-κB in non-lymphoid cells such as fibroblasts and renal mesangial cells. We further show that FK506 induces NF-κB-regulated IL-6 production in vitro and in vivo, in particular in kidney. IL-6 has been shown previously to produce renal abnormalities in vivo, such as mesangioproliferative glomerulonephritis. Similar renal abnormalities were also observed in FK506-treated animals. These results thus suggest a causal relationship between FK506-induced NF-κB activation/IL-6 production and some of FK506-induced renal abnormalities. |
| Databáze: | OpenAIRE |
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