Cholestasis in Preterm Infants
| Autor: | Katie Satrom, Glenn R. Gourley |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Fat Emulsions Intravenous Parenteral Nutrition Antifungal Agents Gastrointestinal Diseases Gestational Age Enteral administration Severity of Illness Index Sepsis 03 medical and health sciences 0302 clinical medicine Enteral Nutrition Cholestasis Enterocolitis Necrotizing Risk Factors 030225 pediatrics medicine Humans Intensive care medicine Fluconazole Liver injury business.industry Infant Newborn Obstetrics and Gynecology Jaundice medicine.disease Pathophysiology Anti-Bacterial Agents Cephalosporins Parenteral nutrition Pediatrics Perinatology and Child Health Etiology 030211 gastroenterology & hepatology medicine.symptom business Infant Premature |
| Zdroj: | Clinics in perinatology. 43(2) |
| ISSN: | 1557-9840 |
| Popis: | Cholestasis in preterm infants has a multifactorial etiology. Risk factors include degree of prematurity, lack of enteral feeding, intestinal injury, prolonged use of parenteral nutrition (PN), and sepsis. Soy-based parenteral lipid emulsions have been implicated in the pathophysiology of PN-associated liver injury. Inflammation plays an important role. Medical therapies are used; however, their effects have not consistently proven effective. Evaluation of cholestasis involves laboratory work; direct bilirubin levels are used for diagnosis and trending. Adverse outcomes include risk for hepatobiliary dysfunction, irreversible liver failure, and death. Early enteral feedings as tolerated is the best way to prevent and manage cholestasis. |
| Databáze: | OpenAIRE |
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