Atomic force microscope images of the surfaces of aspirin crystals at submolecular resolution

Autor:	Kazuo Yokoyama, Katsunosuke Machida, Takao Tohda, Hiroyuki Kado, Norio Masaki
Rok vydání:	1991
Předmět:	Diffraction Aspirin Chemical Phenomena Chemistry Physical Chemistry Mineralogy Cleavage (crystal) General Chemistry General Medicine Electron law.invention Crystal Microscopy Electron Crystallography law Drug Discovery Microscopy Molecule Crystallization Dissolution
Zdroj:	Chemical and Pharmaceutical Bulletin. 39:1899-1901
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.39.1899
Popis:	The atomic force microscope has been developed and used to image arrays of molecules at the (001) and (100) faces of aspirin crystals in water and in air. Lattice spacings composed of methyl groups and the part of the phenyl groups on the surface of the (001) in water, are consistent with X-ray diffraction data. The surface of (100) face which shows most perfect cleavage in bulk, is more difficult to image. This initial success in imaging at drug crystal surfaces clarified the different structural behavior at the submolecular level for three crystal faces, and the close relationship to the differences in the dissolution velocity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea01cf62020519b612e38fd8121a1025 https://doi.org/10.1248/cpb.39.1899 Zobrazit plný text záznamu