Transcription co-activator SAYP mediates the action of STAT activator
| Autor: | Semen A. Doronin, Yulii V. Shidlovskii, Marina R. Kopantseva, Elena N. Nabirochkina, Sofia G. Georgieva, Nadezhda E. Vorobyeva, Julia L. Kuzmina, V. V. Panov |
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| Rok vydání: | 2011 |
| Předmět: |
Transcriptional Activation
Activator (genetics) Gene Regulation Chromatin and Epigenetics Biology Molecular biology stat Cell Line STAT Transcription Factors Phenotype Transcription (biology) Mutation Genetics Animals Drosophila Proteins Drosophila Protein Interaction Domains and Motifs Protein inhibitor of activated STAT Signal transduction Transcription factor STAT4 Transcription Factors STAT6 |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkr1165 |
| Popis: | Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven transcription of numerous genes. Mutation of SAYP leads to maldevelopments similar to those observed in STAT mutants. Thus, SAYP is a novel co-activator mediating the action of STAT. |
| Databáze: | OpenAIRE |
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