Waist circumference increases risk of coronary heart disease: Evidence from a Mendelian randomization study

Autor: Kai Huang, Chen Yao, Ridong Wu, Lingling Li, Qinchang Chen, Runnan Shen, Junzhe Yi
Rok vydání: 2020
Předmět:
Zdroj: Molecular Genetics & Genomic Medicine, Vol 8, Iss 4, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine
ISSN: 2324-9269
DOI: 10.1002/mgg3.1186
Popis: Background This study investigated whether expanding waist circumference (WC) is causally associated with an elevated risk of coronary heart disease (CHD), using a two‐sample Mendelian randomization (MR) study through integrating summarized data from genome‐wide association study. Methods The data included in this analysis were mainly from the Genetic Investigation of ANthropometric Traits (GIANT), Consortium and Coronary Artery Disease Genome wide Replication, and Meta‐analysis plus the Coronary Artery Disease (C4D) Genetics (CARDIoGRAMplusC4D) Consortium. Three statistical approaches, inverse‐variance weighted (IVW), weighted median, and MR‐Egger regression method were conducted to assess the casual relationship. The exposure was WC, measured by 46 single‐nucleotide polymorphisms from GIANT and the outcome was the risk of CHD. Then, we used the genetic data from Neale Lab and TAG to infer whether WC causally affected the established risk factors of CHD. Results The IVW method presented that genetically predicted WC was positively casually associated with CHD (odds ratio [OR]: 1.57, 95% CI = 1.33–1.84; p = 4.81e‐08), which was consistent with the result of weighted median and MR‐Egger regression. MR‐Egger regression indicated that there was no directional horizontal pleiotropy to violate the MR assumption. Additionally, expanded WC was also associated with higher risk of hypertension and diabetes, higher cholesterol, more smoking intensity, and decreased frequency of physical activity. Conclusion Our analysis provided strong evidence to indicate a causal relationship between WC and increased risk of CHD.
Our results indicated that 12.5 cm increased waist circumference (WC) predicted more than 1.5‐folds increased risk of coronary heart disease (CHD). We have identified that lager WC was statistically associated with hypertension, diabetes, smoking, high cholesterol, and decreased physical activity, which were established risk factors of CHD.
Databáze: OpenAIRE
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