Reaction of bone marrow hematopoiesis to the toxic effect of paclitaxel
| Autor: | V. E. Gol’dberg, O. V. Pershina, E. P. Feodorova, E. G. Skurikhin, O. V. Kolotova, Karpova Gv, A. A. Churin, Voronova Ol |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Paclitaxel medicine.medical_treatment Intraperitoneal injection Bone Marrow Cells General Biochemistry Genetics and Molecular Biology Mice chemistry.chemical_compound Precursor cell medicine Animals Stem Cells General Medicine medicine.disease Antineoplastic Agents Phytogenic Pancytopenia Hypoplasia Hematopoiesis Haematopoiesis medicine.anatomical_structure chemistry Mice Inbred CBA Cancer research Erythropoiesis Bone marrow |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 145:213-217 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Intraperitoneal injection of paclitaxel (Mitotax) in a single dose of 40 mg/kg was followed by an increase in the number of mitotic granulocytic and erythroid cells, hypoplasia, and pancytopenia of the bone marrow in CBA/CaLac mice. The test preparation decreased the number of hematopoietic precursor cells for erythropoiesis and granulocytopoiesis, but increased the count of polyploid cells and incidence of structural and genomic abnormalities in bone marrow cells. These changes were reversible. |
| Databáze: | OpenAIRE |
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