Reference Ranges for Exhaled Nitric Oxide Fraction in Healthy Japanese Adult Population
| Autor: | Hisamichi Aizawa, Takahiro Tsuburai, Tomotaka Kawayama, Kazuto Matsunaga, Kazuo Akiyama, Ken Ohta, Masakazu Ichinose, Hiroyuki Nagase, Tsunahiko Hirano |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy Percentile medicine.medical_specialty ethnic difference Adolescent atopy Adult population airway inflammation Nitric Oxide Gastroenterology smoking Japan Predictive Value of Tests Reference Values Internal medicine Respiratory Hypersensitivity medicine Humans Immunology and Allergy Aged business.industry Airway inflammation Exhalation General Medicine Middle Aged respiratory system asthma respiratory tract diseases Breath Tests Anesthesia Predictive value of tests Exhaled nitric oxide Female Geometric mean lcsh:RC581-607 business Body mass index Biomarkers |
| Zdroj: | Allergology International, Vol 59, Iss 4, Pp 363-367 (2010) |
| ISSN: | 1323-8930 |
| Popis: | Background The measurement of the exhaled nitric oxide fraction (FEno) is proposed as a useful marker of airway inflammation. In healthy adults, there have been a few studies of the reference ranges for FE no in Caucasians. A community study in other regions may reveal any possible ethnic differences in the FE no levels. Methods A total of 240 healthy adults aged between 18 to 74 years were recruited from four medical centers in Japan. Current smokers and subjects having a history of atopic disease were not included. FE no was measured using an online electrochemical nitric oxide analyzer according to the current guidelines. The reference ranges for FE no were estimated using two different statistical methods recommended by International Federation of Clinical Chemistry and Laboratory Medicine. Results The mean FE no was 16.9 ppb (parts per billion) with a 95% prediction interval (2.5 to 97.5 percentiles) of 6.5 to 35.0 ppb in healthy Japanese adults. Normality assumptions were met for the logarithm- transformed FE no. The geometric mean FE no was 15.4 ppb with a mean ± two standard deviations of 6.5 to 36.8 ppb. Age, gender, height, and past smoking history were not associated with the FE no levels. Conclusions The reference ranges for FE no in healthy Japanese adults were similar to those of Caucasians. It seems reasonable that the upper limit of FE no for healthy adults should be set at approximately 36.0 ppb irrespective of ethnic differences. |
| Databáze: | OpenAIRE |
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