Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
| Autor: | Hiroyuki Yamazaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Organohalogens
Marine conservation Aquatic Organisms Biological Products Organic product Natural product Marine invertebrates Biological activities Pharmacology toxicology Fungi Review MONOTORI Natural resource Protein Tyrosine Phosphatase 1B chemistry.chemical_compound chemistry Indonesia Natural Resources Biological property Molecular Medicine Biochemical engineering |
| Zdroj: | Journal of Natural Medicines |
| ISSN: | 1861-0293 1340-3443 |
| DOI: | 10.1007/s11418-021-01557-3 |
| Popis: | Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol O-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study. Graphic abstract |
| Databáze: | OpenAIRE |
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