Ryanodine Receptor as Insecticide Target
| Autor: | Yunxun Xie, Ruifang Ma, Rajamanikandan Sundarraj, Arthur Samurkas, Han Zuilhof, Zhiguang Yuchi, Li Yao, Hadiatullah Hadiatullah |
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| Rok vydání: | 2022 |
| Předmět: |
Target
Insecticides Flubendiamide media_common.quotation_subject Resistance Insect Biology Agricultural pest Insecticide Resistance chemistry.chemical_compound Drug Discovery Animals Humans Cyantraniliprole Beneficial insects Calcium Signaling Insecticide VLAG media_common Diamide Mammals Pharmacology Genetics Low toxicity Ryanodine receptor Organic Chemistry fungi Ryanodine Receptor Calcium Release Channel musculoskeletal system Highly selective Organische Chemie chemistry cardiovascular system Structural biology tissues |
| Zdroj: | Current Pharmaceutical Design, 28(1), 26-35 Current Pharmaceutical Design 28 (2022) 1 |
| ISSN: | 1381-6128 |
| Popis: | The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc., targets insect RyRs and can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals, fishes, and beneficial insects. However, recently mutations identified on insect RyRs have emerged and caused resistance in several major agricultural pests throughout different continents. This review paper summarizes the recent findings on the structure and function of insect RyRs as insecticide targets. Specifically, we examine the structures of RyRs from target and non-target species, which reveals the molecular basis for insecticide action and selectivity. We also examine the structural and functional changes of RyR caused by the resistance mutations. Finally, we examine the progress in RyR structure-based insecticide design and discuss how this might help the development of a new generation of green insecticides. |
| Databáze: | OpenAIRE |
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