3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study

Autor: Janan Abbas, Daniel Barazany, Bahaa Medlej, Einat Kedar, Daniel Stein, Haim Cohen, Yaniv Assaf, Israel Hershkovitz, Gali Dar, Ori Hay, Viviane Slon
Jazyk: angličtina
Rok vydání: 2021
Předmět:
musculoskeletal diseases
Modern medicine
MRI diffusion
Materials science
Evolution
Science
0206 medical engineering
Hydrostatic pressure
Imaging techniques
Intervertebral Disc Degeneration
02 engineering and technology
Microscopy
Atomic Force
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Imaging
Three-Dimensional
0302 clinical medicine
Virtual reconstruction
Image Processing
Computer-Assisted
Quantitative assessment
medicine
Humans
Dti tractography
Multidisciplinary
Annulus Fibrosus
Intervertebral disc
Plastic Surgery Procedures
musculoskeletal system
Magnetic Resonance Imaging
020601 biomedical engineering
Cartilage
medicine.anatomical_structure
Surgery
Computer-Assisted
Medicine
Evolutionary developmental biology
Annulus (zoology)
Anatomy
Intervertebral Disc Displacement
Biomedical engineering
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
ISSN: 2045-2322
Popis: The intervertebral disc’s (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion, and maintains the integrity of the motion segment. The microstructure of the AF is not yet fully understood and quantitative characterization is lacking, leaving a caveat in modern medicine’s ability to prevent and treat disc failure (e.g., disc herniation). In this study, we show a reconstruction of the 3D microstructure of the fibers that constitute the AF via MRI diffusion tensor imaging (DTI) followed by fiber tracking. A quantitative analysis presents an anisotropic structure with significant architectural differences among the annuli along the width of the fibrous belt. These findings indicate that the outer annuli's construction reinforces the IVD while providing a sufficient degree of motion. Our findings also suggest an increased role of the outer annuli in IVD nourishment.
Databáze: OpenAIRE
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