Asymmetric Division in the Immuno-Hematopoietic System

Autor: Daniel Jimenez-Teja, Matilde Cañelles, Nadia Martin-Blanco
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Hematology-Science and Practice
Popis: Asymmetric division is a process by which stem cells asymmetrically segregate certain proteins, called “cell fate determinants”, in order to generate two functionally different cells. Normally, one of the daughter cells terminally differentiates while the other retains stem cell properties and continues proliferating. Asymmetric division has been found in virtually all developing systems where stem cells need to simultaneously proliferate and generate differentiated cells: brain, skin, gut, mammary gland, hematopoiesis, also in plants and algae. As a consequence of these studies, it has been established that, by virtue of asymmetric division, both developing and adult organs maintain the delicate equilibrium between proliferation and differentiation. The recent discovery of links to cancer has added momentum to an already very dynamic research area. This review article will discuss the latest developments in the asymmetric division field, with a focus on the immunohematopoietic system.
Databáze: OpenAIRE
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