18F-Sodium Fluoride Uptake Is a Marker of Active Calcification and Disease Progression in Patients With Aortic Stenosis
| Autor: | Alison Fletcher, Mark Pringle, Calvin W. L. Chin, Tamir Malley, William Jenkins, William A Wallace, David E. Newby, Edwin J R van Beek, James H.F. Rudd, Marc R. Dweck, Renzo Pessotto, Vasiliki Tsampasian, William J.A. Cowie, Alex T. Vesey, Hamish Richardson, Nicholas A. Boon |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aortic valve Fluorine Radioisotopes medicine.medical_specialty Urology Severity of Illness Index Aortic valve replacement Fluorodeoxyglucose F18 Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over PET-CT biology business.industry Calcinosis Reproducibility of Results Aortic Valve Stenosis medicine.disease Stenosis medicine.anatomical_structure Positron-Emission Tomography Aortic valve stenosis Disease Progression Cardiology Osteocalcin biology.protein Sodium Fluoride Female Aortic valve calcification Cardiology and Cardiovascular Medicine business Biomarkers Calcification |
| Zdroj: | Circulation: Cardiovascular Imaging. 7:371-378 |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.113.001508 |
| Popis: | Background— 18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are promising novel biomarkers of disease activity in aortic stenosis. We compared 18F-NaF and 18F-FDG uptake with histological characterization of the aortic valve and assessed whether they predicted disease progression. Methods and Results— Thirty patients with aortic stenosis underwent combined positron emission and computed tomography using 18F-NaF and 18F-FDG radiotracers. In 12 patients undergoing aortic valve replacement surgery (10 for each tracer), radiotracer uptake (mean tissue/background ratio) was compared with CD68 (inflammation), alkaline phosphatase, and osteocalcin (calcification) immunohistochemistry of the excised valve. In 18 patients (6 aortic sclerosis, 5 mild, and 7 moderate), aortic valve computed tomography calcium scoring was performed at baseline and after 1 year. Aortic valve 18F-NaF uptake correlated with both alkaline phosphatase ( r =0.65; P =0.04) and osteocalcin ( r =0.68; P =0.03) immunohistochemistry. There was no significant correlation between 18F-FDG uptake and CD68 staining ( r =−0.43; P =0.22). After 1 year, aortic valve calcification increased from 314 (193–540) to 365 (207–934) AU ( P r =0.66; P r =0.75; P r =−0.11; P =0.66). Conclusions— 18F-NaF uptake identifies active tissue calcification and predicts disease progression in patients with calcific aortic stenosis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01358513. |
| Databáze: | OpenAIRE |
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