Liver-Unrelated Comorbid Conditions do not impact Cognitive Performance or Hepatic Encephalopathy Progression in Cirrhosis
| Autor: | HoChong Gilles, Michael Fuchs, Scott C. Matherly, Omar Nadhem, Andrew Fagan, Leroy R. Thacker, Hannah Lee, Mohammad S. Siddiqui, Felicia Tinsley, Sara McGeorge, Ramzi Hassouneh, Arun J. Sanyal, Richard K. Sterling, Douglas M. Heuman, Jasmohan S Bajaj, Puneet Puri, Velimir A. Luketic, Chathur Acharya, James B. Wade, Jawaid Shaw |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology Proportional hazards model business.industry medicine.drug_class Gastroenterology Proton-pump inhibitor medicine.disease Article 03 medical and health sciences Liver disease 0302 clinical medicine 030220 oncology & carcinogenesis Diabetes mellitus Internal medicine medicine 030211 gastroenterology & hepatology Effects of sleep deprivation on cognitive performance business Hepatic encephalopathy Depression (differential diagnoses) |
| Zdroj: | Am J Gastroenterol |
| Popis: | Introduction We aimed to determine the effect of comorbidities on covert hepatic encephalopathy (CHE) diagnosis and overt hepatic encephalopathy (OHE) development. Methods Cirrhotic outpatients underwent CHE testing and 2-year follow-up. Cox regression was performed for time to OHE. In total, 700 patients (60 years, 84% men, model for end-stage liver disease 11) and 33% prior OHE underwent testing and follow-up. Results Major comorbidities were hypertension (54%), diabetes (35%), and depression (29%). Common medications were proton pump inhibitor (49%), beta-blockers (32%), and opioids (21%). Approximately 90 (40%) prior-OHE patients developed recurrence 93 (30,206) days post-testing predicted only by liverrelated variables. Discussion Demographics, cirrhosis characteristics, and opioid use, but not other comorbid conditions, were associated with CHE diagnosis and OHE progression. |
| Databáze: | OpenAIRE |
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