Rapid multifocal chondrolysis after liver transplantation in four patients
| Autor: | J Taillandier, D Samuel, F. Liote, Bismuth H, M Alemanni |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Knee Joint Concise Report Joint replacement Inflammatory arthritis medicine.medical_treatment Immunology Osteoporosis Liver transplantation General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine medicine Humans Immunology and Allergy Retrospective Studies business.industry Retrospective cohort study Middle Aged medicine.disease Liver Transplantation Surgery Radiography Transplantation Female Hip Joint Complication business Cartilage Diseases |
| Zdroj: | Annals of the Rheumatic Diseases. 65:118-120 |
| ISSN: | 0003-4967 |
| Popis: | Background: Favourable clinical outcomes achieved with liver transplantation may be jeopardised by corticosteroid-induced osteoarticular complications, such as osteoporosis or aseptic osteonecrosis. Case report: A previously unreported joint complication in liver transplant recipients is described. Methods: Retrospective study of liver transplant recipients in whom destructive joint disease developed, identified among 330 symptomatic patients out of a total of 1260 managed over a 15 year period (November 1984-January 2000) in a university based liver transplantation centre. Results: In four patients (23–56 years), rapid chondrolysis developed 2–12 years after transplantation in more than three weightbearing or non-weightbearing joints free of radiological features of avascular osteonecrosis, evidence of infection, or defined inflammatory arthritis. Pathological examination of five hip joints and one knee joint found no evidence of infection or inflammation. Six joint replacement procedures were performed successfully in three patients. Conclusion: Clinicians managing liver transplant recipients, and perhaps recipients of other organs, should be aware that rapid chondrolysis may develop. The pathogenesis of this rare complication is unclear. |
| Databáze: | OpenAIRE |
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