Effect of a Recombinant CD4-IgG on In Vitro T Helper Cell Function: Data from a Phase I/II Study of Patients with AIDS
| Autor: | Mario Clerici, Stephen P. Blatt, Craig W. Hendrix, Arthur J. Ammann, Samuel Broder, Robert Yarchoan, Gene M. Shearer |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cellular immunity
medicine.medical_treatment In Vitro Techniques medicine.disease_cause Immune system Antigen Immunopathology Leukocytes Influenza A virus Humans Immunology and Allergy Medicine Acquired Immunodeficiency Syndrome business.industry T-Lymphocytes Helper-Inducer Immunotherapy T lymphocyte T helper cell Recombinant Proteins Infectious Diseases medicine.anatomical_structure Immunoglobulin G CD4 Antigens Immunology Interleukin-2 business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Ten patients with AIDS were enrolled in a phase I/II protocol of recombinant CD4-IgG (rCD4-IgG) treatment. Patients' peripheral blood leukocytes (PBL) were tested before, during, and after therapy with rCD4-IgG for T helper (TH) cell function assessed by antigen- and mitogen-stimulated proliferation and interleukin-2 production in response to influenza A virus, allogeneic PBL (alloantigens), and phytohemagglutinin. Although clinical benefit was not evident, rCD4-IgG treatment was associated with rapid and potent improved TH cell function for two of three stimuli tested in 90% of the patients. These data are complemented by an in vitro experimental model that demonstrates the opposing immunologic effects of rgp120 and rCD4-IgG on TH cell function of PBL from uninfected individuals. Thus, restoration of TH cell function by rCD4-IgG in the absence of increased CD4 cell counts could be due to removal of an immunosuppressive factor, possibly gp120. These findings suggest that rCD4-IgG can induce partial restoration of immune function in AIDS patients, even in the absence of apparent short-term clinical benefit. |
| Databáze: | OpenAIRE |
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