Affective Dysregulation in Children Is Associated With Difficulties in Response Control in Emotional Ambiguous Situations
| Autor: | Christian Beste, Franziska Giller, Daniel Brandeis, Pascal-M Aggensteiner, Manfred Döpfner, Tobias Banaschewski, Veit Roessner |
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| Rok vydání: | 2022 |
| Předmět: |
Cognitive Neuroscience
media_common.quotation_subject Emotions Dysfunctional family Brodmann area 10 Anger Irritability 050105 experimental psychology 03 medical and health sciences Cognition 0302 clinical medicine Brodmann area 47 medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Child Biological Psychiatry media_common Aggression 05 social sciences Information processing Bayes Theorem Electroencephalography Stroop Test Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery Cognitive psychology Stroop effect |
| Zdroj: | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:66-75 |
| ISSN: | 2451-9022 |
| DOI: | 10.1016/j.bpsc.2021.03.014 |
| Popis: | Background Affective dysregulation (AD), or synonymously "irritability," is a transdiagnostic construct that serves as a diagnostic criterion in various childhood mental disorders. It is characterized by severe or persistent outbursts of anger and aggression. Emotional self-regulation is highly dependent on the ability to process relevant and ignore conflicting emotional information. Understanding neurophysiological mechanisms underlying impairment in AD may provide a starting point for research on pharmacological treatment options and evaluation of psychotherapeutic intervention. Methods A total of 120 children 8 to 12 years of age (63 with AD and 57 typically developing) were examined using an emotional Stroop task. Signal-decomposed electroencephalographic recordings providing information about the affected sensory–perceptual, response selection, or motor information processing stage were combined with source localization. Results Behavioral performance revealed dysfunctional cognitive-emotional conflict monitoring in children with AD, suggesting difficulties in differentiating between conflicting and nonconflicting cognitive-emotional information. This was confirmed by the electroencephalographic data showing that they cannot intensify response selection processes during conflicting cognitive-emotional situations. Typically developing children were able to do so and activated a functional–neuroanatomical network comprising the left inferior parietal cortex (Brodmann area 40), right middle frontal (Brodmann area 10), and right inferior/orbitofrontal (Brodmann area 47) regions. Purely sensory–perceptual selection and motor execution processes were not modulated in AD, as evidenced by Bayesian analyses. Conclusions Behavioral and electroencephalogram data suggest that children with AD cannot adequately modulate controlled response selection processes given emotionally ambiguous information. Which neurotransmitter systems underlie these deficits and how they can be improved are important questions for future research. |
| Databáze: | OpenAIRE |
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