Multidrug resistance and anticonvulsants: new studies with some enaminones
| Autor: | Debra Payne, Tiffany L. Wilson, Noha N. Salama, Natalie D. Eddington, Kenneth R. Scott |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_treatment
Cell Pharmacology Biochemistry Pharmacokinetics Drug Discovery medicine Distribution (pharmacology) Animals Humans ATP Binding Cassette Transporter Subfamily B Member 1 P-glycoprotein biology Chemistry Cyclohexanones Organic Chemistry Brain Drug Resistance Multiple Multiple drug resistance Anticonvulsant medicine.anatomical_structure Cancer cell biology.protein Molecular Medicine Anticonvulsants Efflux Multidrug Resistance-Associated Proteins |
| Zdroj: | Current medicinal chemistry. 11(15) |
| ISSN: | 0929-8673 |
| Popis: | The multidrug resistance (MDR), often conferred by the active extrusion of drugs from the cell, is a phenomenon often seen in cancer cells that may become resistant to a wide spectrum of drugs with varying chemical structures or cellular targets. This event has recently been reported for anticonvulsants. Studies in our laboratories on this occurrence with some enaminones have shown that the enaminones display high efflux ratios and are recognized by P-glycoprotein (P-gp) and/or the multidrug resistance protein (MRP), which have been reported as the main efflux transporters responsible for the development of MDR. Recent studies have uncovered interesting structural analogues that can modulate the functional activity of P-gp, suggesting a possible increase in the bioavailabillity of P-gp substrate drugs when administered concurrently. |
| Databáze: | OpenAIRE |
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