Regulation of tyrosine protein kinase receptor Trk-B and motor function in rats following cardiac arrest
| Autor: | S.P. Jaw, D.D. Su, Q.-V.T. Vuong, Daniel D. Truong |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Myoclonus Cerebellum medicine.medical_specialty Resuscitation Immunoblotting Clinical Biochemistry Ischemia Striatum Motor Activity Biology Toxicology Biochemistry Rats Sprague-Dawley Behavioral Neuroscience Internal medicine Image Processing Computer-Assisted medicine Animals Tyrosine Receptor Protein kinase A Biological Psychiatry Brain Chemistry Pharmacology Receptor Protein-Tyrosine Kinases medicine.disease Heart Arrest Rats medicine.anatomical_structure Endocrinology Trk receptor |
| Zdroj: | Pharmacology Biochemistry and Behavior. 52:443-446 |
| ISSN: | 0091-3057 |
| Popis: | Following 10 min cardiac arrest and resuscitation, male Sprague-Dawley rats developed posthypoxic myoclonus. Sixty days later, the motor function of the animals was restored. In the present study, we investigated brain levels of tyrosine protein kinase receptor Trk-B with quantitative immunoblot analysis at various time points following cardiac arrest. In the frontal cortex, a significant reduction of Trk-B was found in rats 3 days (53%) after cardiac arrest, whereas significant increases were detected in rats 14 (124%) and an average 60 days (98%) after cardiac arrest. In the striatum, significant increases were found in rats 3 (389%), 14 (483%), and 60 days (521%) after resuscitation. In contrast, significant reductions of Trk-B were detected in the cerebellum of rats 3 (46%), 14 (22%), and 60 days (18%) after cardiac arrest. The results indicate that regulation of Trk-B may vary in different brain regions and have important roles in recovery processes following hypoxic-ischemic insults to the brain. |
| Databáze: | OpenAIRE |
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