Leptin and its Receptors in Human Placenta of Small, Adequate, and Large for Gestational Age Newborns
| Autor: | Juan Manuel Malacara, Maria-Luisa Lazo-de-la-Vega-Monroy, Gloria Barbosa-Sabanero, Leonel Daza-Benítez, Myrna Sabanero, Silvio Zaina, Martha I. González-Domínguez |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Leptin 0301 basic medicine medicine.medical_specialty Placenta Endocrinology Diabetes and Metabolism Birth weight Clinical Biochemistry 030209 endocrinology & metabolism Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal medicine medicine Humans reproductive and urinary physiology Leptin receptor Anthropometry business.industry Biochemistry (medical) Infant Newborn Gestational age Organ Size General Medicine Fetal Blood medicine.disease 030104 developmental biology medicine.anatomical_structure Cord blood Infant Small for Gestational Age Receptors Leptin Gestation Female business |
| Zdroj: | Hormone and Metabolic Research. 49:350-358 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-0043-103345 |
| Popis: | Alterations in birth weight impact postnatal outcome and adult metabolic health. Therefore, fetal growth regulation is crucial for preventing chronic metabolic diseases. Leptin has been suggested to play an important role in placental and fetal growth, albeit its specific mechanisms of action have not been elucidated. The aim of this study was to analyze leptin concentrations in placenta, cord blood, and maternal blood of SGA, AGA, and LGA (small, adequate and large for gestational age, respectively) newborns, as well as placental leptin receptor (LEPRa and LEPRb) protein expression. We performed a cross-sectional comparative study in 3 groups of healthy mothers and their term newborns at delivery (SGA, AGA, and LGA, n=20 per group). Placental, maternal blood, and cord blood leptin content were measured by ELISA. Placental LEPRa and LEPRb protein expression were determined by Western Blot. Maternal leptin concentrations correlated positively with maternal weight before and at the end of gestation, without differences between groups. Cord leptin is higher in LGA and lower in SGA, whereas placental leptin is higher in SGA. Placental leptin was inversely correlated with placental weight, independently from maternal weight and gestational age. Both LEPRa and LEPRb expression are lower in SGA, while LEPRa positively correlated with placental weight and birthweight. The current findings indicate that placental leptin and its receptors are differentially expressed in SGA, AGA, and LGA newborns. We suggest that placental leptin and LEPR protein expression may influence placental growth and thus, birth weight. |
| Databáze: | OpenAIRE |
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