A case of mitochondrial cardiomyopathy with restrictive transmitral filling pattern
| Autor: | Kazuo Onishi, Anna Tamagawa, Nobutaka Inoue, Kazunori Otsui |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
transmitral flow
medicine.medical_specialty business.industry Pleural effusion Mitochondrial disease Furosemide Case Report General Medicine medicine.disease Brain natriuretic peptide A3243G mutation Eplerenone mitochondrial disease medicine.anatomical_structure Ventricle Internal medicine Heart failure medicine Cardiology diastolic dysfunction Enalapril business medicine.drug |
| Zdroj: | International Medical Case Reports Journal |
| ISSN: | 1179-142X |
| Popis: | A 61-year-old diabetic woman with a mitochondrial A3243G mutation was hospitalized for evaluation of breathlessness, general fatigue, and leg edema. Chest radiography revealed cardiomegaly with massive pleural effusion. Serum lactate, pyruvate, and brain natriuretic peptide concentrations were elevated. Transthoracic echocardiography revealed a restrictive pattern of transmitral flow, although systolic function of the left ventricle was only mildly impaired. Based on these findings and her clinical course, the patient was diagnosed with right-sided heart failure caused by mitochondrial cardiomyopathy associated with a restrictive transmitral filling pattern. Treatment with furosemide, enalapril, and eplerenone was effective, and improvement in her symptoms was associated with amelioration of transthoracic echocardiographic findings and a reduction in serum brain natriuretic peptide levels. Previous reports have indicated heterogeneity in the clinical features of mitochondrial cardiomyopathy in patients carrying the A3243G mutation; the present case highlights the substantial variability in the clinical features of this disease. |
| Databáze: | OpenAIRE |
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