Effects of Clonidine and Flesionoxan on Blood Pressure Variability in Conscious Spontaneously Hypertensive Rats
| Autor: | Berthe Fournier, Stéphane Laurent, Michel E. Safar, Hubert Dabiré, Kamel Chaouche-Teyara, Patrick Lacolley, Pascal Challande |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Time Factors Baroreceptor Injections Subcutaneous Receptors Drug Imidazoline receptor Blood Pressure Clonidine Piperazines Heart Rate Rats Inbred SHR Internal medicine Flesinoxan Adrenergic alpha-2 Receptor Agonists medicine Animals Antihypertensive Agents Pharmacology business.industry Rats Endocrinology Blood pressure Hypertension Imidazoline Receptors 5-HT1 receptor Serotonin Cardiology and Cardiovascular Medicine business Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 30:241-244 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199708000-00014 |
| Popis: | Summary: The effects of two centrally acting antihypertensive agents, clonidine (0.1 mg/kg/day s.c.) and flesinoxan (1 mg/kg/day s.c.), on short-term blood pressure variability (BPV) were investigated in conscious spontaneously hypertensive rats (SHRs). The drugs were infused subcutaneously during 24 h and 4 weeks by osmotic minipumps. BPV was characterized by spectral analysis. In conscious SHRs, clonidine significantly and preferentially reduced the low frequency (LF; 0.25-0.75 Hz) oscillations of mean arterial pressure (MAP) in short-term (24 h) and long-term (4 weeks) treatments but significantly decreased MAP level only in short-term treatments. In contrast, flesinoxan significantly reduced MAP level whatever the duration of infusion but decreased LF-MAP only in short-term treatments. These results show that centrally mediated inhibition of sympathetic tone by stimulation of either α2-adrenoceptors or 5-HT1A (serotonin) receptors can reduce BPV. This effect is independent of the modifications in BP level. The effects of the drugs on baroreceptors may also contribute to the decrease in BPV. The dual properties of clonidine (α2-adrenoceptors and imidazoline receptors) may account for its differential effects on BP level and BPV. |
| Databáze: | OpenAIRE |
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