Preoperative serum levels of YKL 40 and CA125 as a prognostic indicators in patients with endometrial cancer

Autor: Malgorzata Fuksiewicz, Michal Wagrodzki, Maria Kowalska, Joanna Jonska-Gmyrek, Beata Kotowicz
Rok vydání: 2017
Předmět:
Adult
musculoskeletal diseases
medicine.medical_specialty
endocrine system diseases
Disease
Sensitivity and Specificity
Gastroenterology
Disease-Free Survival
03 medical and health sciences
Gynecologic Surgical Procedures
0302 clinical medicine
Internal medicine
Biomarkers
Tumor
medicine
Humans
In patient
Chitinase-3-Like Protein 1
Stage (cooking)
Elisa method
Lymph node
Aged
Neoplasm Staging
Aged
80 and over
Gynecology
030219 obstetrics & reproductive medicine
business.industry
Endometrial cancer
Membrane Proteins
Obstetrics and Gynecology
Middle Aged
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Endometrial Neoplasms
Survival Rate
Treatment Outcome
medicine.anatomical_structure
Reproductive Medicine
CA-125 Antigen
030220 oncology & carcinogenesis
Preoperative Period
Biomarker (medicine)
Female
Lymph
Neoplasm Recurrence
Local
business
Zdroj: European Journal of Obstetrics & Gynecology and Reproductive Biology. 215:141-147
ISSN: 0301-2115
DOI: 10.1016/j.ejogrb.2017.06.021
Popis: Objective To evaluate the utility of YKL-40 and CA125 in endometrial cancer (EC) patients, and to determine their prognostic value in assessing the disease-free survival (DFS) and overall survival (OS). Methods We analyzed seventy-four EC patients, treated at a single institution and 25 healthy individuals. CA 125 serum level was evaluated in the Cobas 6000 system and YKL-40, using the ELISA method. Results Significantly increased serum level of YKL-40 and CA125 was in EC patients in FIGO I-IB when compared to healthy controls. CA125 was significantly higher in patients with more advanced FIGO stage vs. FIGO I, and also in patients with lymph node metastases vs. patients with no metastases. The obtained AUC for YKL-40 was higher than for CA125. There was, however, higher diagnostic sensitivity for YKL-40 in comparison to CA125, both in patients with type I and type II tumours. In patients who had disease progression, both the percentage of elevated concentration of CA 125 and YKL-40 was higher than in patients with remission. The Chi2 test demonstrated the statistically significant differences. The predictive value of CA125 in an aspect of DFS and OS was demonstrated. Conclusions A high diagnostic sensitivity of YKL-40 in the early stages of the disease suggests the possibility of using this biomarker at an early diagnostic phase of patients with EC. The patients with increased levels of YKL-40 before treatment are also at the higher risk of relapse. The determination of CA125 before surgery may be helpful in the evaluation of the regional lymph nodes, and is a poor prognostic factor for OS and DFS.
Databáze: OpenAIRE
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