Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice
| Autor: | Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa, André F. Carvalho, Rafaela Carneiro Cordeiro, Charllyany Sabino Custódio, João Henrique Chaves, Danielle Silveira Macêdo, Fernanda Yvelize Ramos de Araújo, Hélio Vitoriano Nobre Júnior, Mariana Lima Vale, Bruna Stefânia Ferreira Mello |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Reflex Startle Time Factors Hippocampus Prefrontal Cortex Lipopolysaccharide Motor Activity Rotarod performance test Nitric oxide chemistry.chemical_compound Mice Neuroinflammation Internal medicine medicine Animals Prefrontal cortex Maze Learning Depressive-like behavior Prepulse inhibition Sickness behavior Nitrites Swimming Pharmacology Óxido Nítrico Behavior Animal Brain Corpus Striatum Motor coordination Inhibition Psychological Endocrinology chemistry Rotarod Performance Test Systemic administration Cytokines Depressão Neuroscience Carboidratos |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | The systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) administration to mice on parameters, such as PPI, depressive- and anxiety-like behaviors, working memory, locomotor activity and motor coordination, 1.5 and 24 h post-LPS administration. IL-1 β and TNF α in the blood and brain as well as brain nitrite levels were evaluated in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). An overall hypolocomotion was observed 1.5 h post-LPS, along with depressive-like behaviors and de fi cits in working memory. Increments in IL-1 β content in plasma and PFC, TNF α in plasma and decreases in nitrite levels in the ST and PFC were also veri fi ed. Twenty-four hours post-LPS treatment, depressive-like behaviors and working memory de fi cits persisted, while PPI levels signi fi cantly reduced along with increases in IL-1 β content in the PFC and a decrease in nitrite levels in the HC, ST and PFC. Our data demonstrate that a delayed increase (i.e., 24 h post-LPS) in PPI levels ensue, which may be useful behavioral parameter for LPS-induced depression. A decrease in nitrergic neurotransmission was associated with these behavioral fi ndings |
| Databáze: | OpenAIRE |
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