Peritransplant Soluble CD30 as a Risk Factor for Slow Kidney Allograft Function, Early Acute Rejection, Worse Long-Term Allograft Function, and Patients’ Survival
| Autor: | Olexandr S. Nykonenko, Svitlana N. Nesterenko, Trailin Av, T. I. Ostapenko, Tamara N Nykonenko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Article Subject Clinical Biochemistry 030232 urology & nephrology Delayed Graft Function Ki-1 Antigen 030230 surgery Gastroenterology Graft function 03 medical and health sciences 0302 clinical medicine Soluble cd30 Risk Factors Internal medicine Genetics medicine Cadaver Living Donors Humans Transplantation Homologous Risk factor Renal Insufficiency Chronic Molecular Biology Survival analysis Kidney transplantation Kidney lcsh:R5-920 business.industry Biochemistry (medical) Graft Survival Patient survival General Medicine Middle Aged medicine.disease Kidney Transplantation Survival Analysis Surgery medicine.anatomical_structure ROC Curve Clinical Study Female business lcsh:Medicine (General) Biomarkers |
| Zdroj: | Disease Markers, Vol 2017 (2017) Disease Markers |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Background.We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes.Methods.Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in predicting delayed graft function, slow graft function (SGF), acute rejection (AR), pyelonephritis, decline of allograft function after 6 months, and graft and patient survival during 5 years of follow-up in 45 recipients.Results.We found the association between low pretransplant serum levels of sCD30 and SGF. The absence of significant decrease of sCD30 on the 4th day posttransplant was characteristic for SGF, early AR (the 8th day–6 months), late AR (>6 months), and early pyelonephritis (the 8th day–2 months). Lower pretransplant and posttransplant sCD30 predicted worse allograft function at 6 months and 2 years, respectively. Higher pretransplant sCD30 was associated with higher frequency of early AR, and worse patients’ survival, but only in the recipients of deceased-donor graft. Pretransplant sCD30 also allowed to differentiate patients with early pyelonephritis and early AR.Conclusions.Peritransplant sCD30 is useful in identifying patients at risk for unfavorable early and late transplant outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text