Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA study
| Autor: | X Zhang, Karen Dempsey, Christine Connors, Federica Barzi, Danielle K. Longmore, Harold David McIntyre, E. L. M. Barr, Louise J. Maple-Brown, Alex Brown, Sujatha Thomas, E Cheng, Paul Zimmet, Jeremy Oats, Marie Kirkwood, Jonathan E. Shaw, D. R. R. Williams, Cherie Whitbread, Jacqueline Boyle, I-Lynn Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Birth weight Population 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Diabetes mellitus Internal Medicine medicine Birth Weight Humans 030212 general & internal medicine education Life Style education.field_of_study Obstetrics business.industry nutritional and metabolic diseases Gestational age General Medicine medicine.disease Pregnancy Complications Gestational diabetes Diabetes Gestational Cohort Female business Body mass index |
| Zdroj: | Diabetes Research and Clinical Practice. 157:107876 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2019.107876 |
| Popis: | Aims To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. Methods Indigenous (n = 97) and Europid (n = 113) women managed by lifestyle modification were compared to women without hyperglycaemia (n = 235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. Results Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73 weeks), lower birthweight z-score (by 0.26, p = 0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), p = 0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), p Conclusion Women with GDM managed by lifestyle modification had higher induction rates and their offspring had lower birthweight z-scores, with a trend to lower LGA than those without hyperglycaemia in pregnancy. Further studies are indicated to explore reasons for higher induction rates. |
| Databáze: | OpenAIRE |
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