Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
| Autor: | Alexander Dobrovic, Matthew Conron, Gavin M. Wright, Genni M Newnham, Kenneth Opeskin, Hongdo Do, Sue-Anne McLachlan, Jason Li, Natalie Thompson, David Thomas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research Lung Neoplasms DNA Mutational Analysis Gene Dosage Disease Biology medicine.disease_cause Bioinformatics lcsh:RC254-282 Metastasis Cohort Studies Carcinoma Non-Small-Cell Lung medicine Genetics Humans Lung cancer Aged Oligonucleotide Array Sequence Analysis Aged 80 and over Mutation Gene Expression Profiling Cancer Middle Aged medicine.disease Aneuploidy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gene expression profiling Gene Expression Regulation Neoplastic Oncology Cancer research Adenocarcinoma Female KRAS Research Article |
| Zdroj: | BMC Cancer, Vol 11, Iss 1, p 93 (2011) BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. Methods Both transcriptional and genomic profiling were performed on 69 resected NSCLC specimens and results correlated with mutational analyses and clinical data to identify genetic alterations associated with groups of interest. Results Combined analyses identified specific patterns of genetic alteration associated with adenocarcinoma vs. squamous differentiation; KRAS mutation; TP53 mutation, metastatic potential and disease recurrence and survival. Amplification of 3q was associated with mutations in TP53 in adenocarcinoma. A prognostic signature for disease recurrence, reflecting KRAS pathway activation, was validated in an independent test set. Conclusions These results may provide the first steps in identifying new predictive biomarkers and targets for novel therapies, thus improving outcomes for patients with this deadly disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|