Lack of Impact of Hyperchloremia in Brain-Dead Organ Donors on the Onset of Kidney Allograft Function in the Recipients
| Autor: | E. Uchytilova, M. Protus, E. Kieslichova, D. Merta, R. Kula, E. Pokorna |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Brain Death Urology Renal function Diuresis Delayed Graft Function Kidney Kidney Function Tests 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hyperchloremia Postoperative Complications Chlorides 030202 anesthesiology Internal medicine medicine Humans 030212 general & internal medicine Kidney transplantation Acute tubular necrosis Retrospective Studies Transplantation Creatinine business.industry Incidence Kidney Tubular Necrosis Acute medicine.disease Allografts Kidney Transplantation Tissue Donors medicine.anatomical_structure Endocrinology Treatment Outcome chemistry Surgery Female business Acidosis Glomerular Filtration Rate |
| Zdroj: | Transplantation proceedings. 49(6) |
| ISSN: | 1873-2623 |
| Popis: | Background Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. Methods We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. Results On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 ± 212.1 μmol/L and 502.2 ± 197.8 μmol/L ( P = .1), on the 7th day, 168.6 ± 102.6 μmol/L and 196.9 ± 120.6 μmol/L ( P = .13), and on the 30th day, 129.4 ± 43.3 μmol/L and 131.8 ± 43.6 μmol/L ( P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. Conclusions In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found. |
| Databáze: | OpenAIRE |
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